Combination of rosiglitazone and SR6452 additively increases adipogenesis. Assessment of aP2 (A), Pparγ2 (B), Pgc-1α (C), AdipoQ (D), or Alas1 (E) mRNA expression during induction of adipogenesis in 3T3-L1 cells either with differentiation media (MDI) or MDI supplemented with rosiglitazone (10 μm), SR6452 (10 μm), or both drugs (10 μm each). F, Treatment of 3T3-L1 cells with a combination of rosiglitazone or SR6452 additively increases lipid accumulation (Oil Red O). *, P < 0.05 vs. control cells at the identical day of treatment; **, P < 0.05 vs. the indicated group.