Table 4.
Stratified logistic regression models of smoking and adenoma occurrence among individuals undergoing screening colonoscopy in the New Hampshire colonscopy Registry from 2004–2006.
| Adenoma v. No Adenoma | |
|---|---|
| Model | Odds Ratio (95% Cl)a |
| Full Model (n = 5,395) | |
| Smoking | |
| No pack-years | 1.00 (referent) |
| 15 pack-years or fewer | 1.07 (0.87–1.32) |
| More than 15 pack-years | 1.54 (1.28–1.86)‡ |
| Sex | |
| Men | 1.00 (referent) |
| Women | 0.53 (0.45–0.62)‡ |
| Family Historyb | |
| Negative | 1.00 (referent) |
| Positive | 1.73 (1.40–2.15)‡ |
| Stratified by Sex | |
| Male (n = 2,284) | |
| No pack-years | 1.00 (referent) |
| 15 pack-years or fewer | 1.32 (1.00–1.76)† |
| More than 15 pack-years | 1.55 (1.21–2.00)‡ |
| Female (n = 3, 111) | |
| No pack-years | 1.00 (referent) |
| 15 pack-years or fewer | 0.85 (0.61–1.14) |
| More than 15 pack-years | 1.55 (1.17–2.05)‡ |
| Stratified by Family History | |
| Negative (n = 4,649) | |
| No pack-years | 1.00 (referent) |
| 15 pack-years or fewer | 1.16 (0.92–1.46) |
| More than 15 pack-years | 1.56 (1.27–1.91‡) |
| Positive (n = 746) | |
| No pack-years | 1.00 (referent) |
| 15 pack-years or fewer | 0.77 (0.4 7–1.26) |
| More than 15 pack-years | 1.50 (0.94–2.38) |
a Odds ratios are adjusted for age in all models, and for family history in the sex-stratified models, and for sex in the family history-stratified models. bFamily history was defined as a reported diagnosis of colon or rectal cancer in a mother, father, sibling, or child of the patient.
†P = .05.
‡P ≤ .001.