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. Author manuscript; available in PMC: 2010 Jul 14.
Published in final edited form as: Biotech Histochem. 2008 Apr;83(2):71–82. doi: 10.1080/10520290802127610

Figure 2.

Figure 2

This figure represents an approach to processing punch biopsies which are typical cores ranging in diameter from 1mm to 5mm. The center of the punch usually represents the lesion. Small punches (top) should not be cut, but should be embedded on their side because cutting prior to processing is likely to result in missing the lesion. Larger punches (bottom) should be cut eccentrically and both parts embedded, cut side down, to best ensure that the central lesion is captured in initial levels.