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. 2010 Mar;89(3):219–229. doi: 10.1177/0022034509359125

Table 3.

Summary of Factors Related to Wound Impairment in Obesity

Local Wound Conditions Associated Diseases and Conditions Factors Altering Immune and Inflammatory Responses

  1. decreased vascularity in adipose tissue

  2. skin folds harbor micro-organisms

  3. friction caused by skin on skin

  4. increased wound tension

  5. increased tissue pressure

  6. hematoma and seroma formation

  7. venous hypertension

  1. hard to reposition

  2. coronary heart disease

  3. atherosclerosis

  4. type 2 diabetes

  5. cancer

  6. hypertension

  7. dyslipidemia

  8. stroke

  9. respiratory problems

  1. adipokines: leptin, adiponectin, resistin

  2. cytokines: TNF-alpha, IL-1, IL-6, IL-8, IL-10

  3. chemokines: IL-8, MCP-1, IP-10

MCP, monocyte chemoattractant protein-1; IP-10 interferon-gamma-inducible protein 10.