Table 1.

Adenovirus tropism and receptor usage.

HAd Subgroups	Serotypes	Predominant natural tropism	Known receptor/s usagea	References
A	12, 18, 31	Gastrointestinal	CAR	Roelvink et al. (1998)
B1	3, 7, 16, 21, 50	Respiratory	CD46, CD80/86, Receptor X, HSPG	Fleischli et al. (2007), Segerman et al. (2003a), Short et al. (2006), Sirena et al. (2004), Tuve et al. (2008)
B2	11, 14, 34, 35	Renal	CD46, CD80/86, Receptor X, HSPG	Fleischli et al. (2007), Segerman et al. (2003a), Segerman et al. (2003b), Short et al. (2006), Tuve et al. (2008)
C	1, 2, 5, 6	Respiratory	CAR, HSPG, MHC-I, VCAM-I, Integrins	Bergelson et al. (1997), Chu et al. (2001), Dechecchi et al. (2000), Hong et al. (1997), Wickham et al. (1993)
D	8, 9, 10, 13, 15, 17, 19, 20, 22–30, 32, 33, 36-39, 42–49, 51	Ocular	CAR, Sialic acid, CD46	Arnberg et al. (2000a), Roelvink et al. (1998)
E	4	Respiratory, Ocular	CAR	Roelvink et al. (1998)
F	40, 41	Gastrointestinal	CAR	Roelvink et al. (1998)

^aListed receptors are suggested to be used by one or more serotypes of the subgroup.