TABLE 1.
Cardiovascular disease risk factors stratified by age among the male Nunavik (Quebec) Inuit population
|
Age, years |
P* | MetS | Framingham risk category | |||||
|---|---|---|---|---|---|---|---|---|
| 20–39 (n=25) | 40–49 (n=224) | 50–59 (n=58) | 60–69 (n=44) | ≥70 (n=38) | ||||
| Body mass index, kg/m2 | 23.7 (0.9) | 26.3 (0.3) | 27.1 (0.7) | 28.3 (0.8) | 29.9 (1.0) | <0.0001 | 5.5 (1.2) | CAD or CAD risk equivalent (10-year risk <20%): 2% |
| Body fat, % | 15.01 (1.6) | 19.3 (0.4) | 21.8 (1.1) | 24.5 (1.1) | 29.0 (1.5) | <0.0001 | ||
| Waist circumference, cm | 81.9 (0.7) | 89.1 (2.4) | 91.3 (1.7) | 96.4 (1.7) | 102.6 (2.4) | <0.0001 | ||
| Systolic BP, mmHg | 121 (1) | 120 (2) | 122 (2) | 129 (2) | 131 (2) | <0.0001 | ||
| Diastolic BP, mmHg | 68 (2) | 76 (2) | 77 (1) | 79 (1) | 73 (1) | 0.043 |
Multiple risk factors and 10-year risk ≤20%: 10% |
|
| TC, mmol/L | 3.8 (0.1) | 4.7 (0.1) | 5.3 (0.1) | 5.4 (0.1) | 5.1 (0.1) | <0.0001 | ||
| TC/HDL-C ratio† | 2.8 (0.1) | 3.4 (0.1) | 3.9 (0.2) | 3.8 (0.2) | 3.2 (0.2) | 0.032 | ||
| HDL-C, mmol/L | 1.4 (0.05) | 1.4 (0.02) | 1.4 (0.05) | 1.5 (0.01) | 1.7 (0.1) | 0.002 | ||
| LDL-C, mmol/L | 2.0 (0.1) | 2.7 (0.001) | 3.2 (0.1) | 3.2 (0.1) | 2.8 (0.2) | <0.0001 | ||
| Triglycerides†, mmol/L | 0.73 (0.04) | 1.1 (0.03) | 1.1 (0.1) | 1.1 (0.1) | 0.9 (0.1) | 0.18 | ||
| HOMA-IR† (n=216) | 1.1 (0.1) | 1.2 (0.04) | 1.3 (0.1) | 1.6 (0.2) | 1.9 (0.3) | 0.03 |
0 to 1 risk factor: 88% |
|
| Fasting glucose†, mmol/L | 4.1 (0.01) | 4.3 (0.04) | 4.7 (0.1) | 4.8 (0.1) | 5.2 (0.2) | <0.0001 | ||
| Fasting insulin†, pmol/L | 43.4 (3.0) | 43.7 (1.4) | 43.7 (3.1) | 51.3 (4.7) | 58.4 (7.8) | 0.016 | ||
| Smoking (yes), % | 100 (–) | 80.3 (2.6) | 82.6 (4.6) | 55.2 (7.3) | 52.7 (7.9) | <0.0001 | ||
| Sedentary lifestyle, % | 40.6 (9.4) | 42.2 (3.7) | 56.2 (7.4) | 57.6 (7.6) | 63.5 (7.8) | 0.01 | ||
Data presented as arithmetic mean (standard error) unless otherwise indicated.
*
P values correspond to a linear trend across age categories;
†
Data presented as geometric mean (standard error). BP Blood pressure; CAD Coronary artery disease; HDL-C High-density lipoprotein cholesterol; HOMA-IR Homeostasis model assessment – insulin resistance; LDL-C Low-density lipoprotein cholesterol; MetS Metabolic syndrome; TC Total cholesterol