Table 6.
Conjunctival Gene Expression Levels* 1 Year after Surgery by Tarsal Conjunctival Inflammation Status
| Gene | Noninflamed (n = 149) |
P‡ | Inflamed (n = 91) |
||||
|---|---|---|---|---|---|---|---|
| Mean† | 95% CI | Median | Mean† | 95% CI | Median | ||
| TNF | 1.66 | 0.65–2.66 | 0.58 | 0.42 | 1.79 | 1.11–2.47 | 0.83 |
| IL1B | 0.39 | 0.15–0.64 | 0.11 | 0.0006 | 1.44 | 0.49–2.40 | 0.20 |
| MMP-1 | 3.08 | 1.56–4.60 | 0.38 | 0.27 | 1.33 | 0.61–2.05 | 0.37 |
| MMP-2 | 0.03 | 0.02–0.04 | 0.02 | 0.035 | 0.12 | 0.00–0.24 | 0.02 |
| MMP-9 | 0.21 | 0.17–0.25 | 0.13 | <0.0001 | 0.54 | 0.33–0.75 | 0.22 |
| TIMP-1 | 16.54 | 12.7–20.4 | 7.05 | 0.16 | 12.21 | 7.13–17.3 | 5.58 |
| TIMP-2 | 5.27 | 4.65–5.90 | 4.31 | 0.32 | 4.71 | 3.91–5.50 | 3.32 |
| MMP-1/TIMP-1 | 0.13 | 0.10–0.16 | 0.06 | 0.78 | 0.10 | 0.08–0.13 | 0.06 |
*
Conjunctival gene expression level of the gene of interest is expressed as a ratio to the HPRT-1 expression level in the same sample.
†
Arithmetic mean of untransformed response.
‡
Interval regression, with P-values adjusted for age, sex, and ethnicity.