Table 1.

Effectiveness of Locally Applied Glutamate on Exciting RGCs in Normal and Degenerated Retinas

	Glutamate Concentration (mM)
	0.4–0.8	2.0	5.0	10.0
Normal Retinas (SD Rat)
All RGCs, 60% (29/48)	20% (1/5)	67.9% (19/28)	50% (3/6)	67% (6/9)
Surface	20% (1/5)	50% (3/6)	100% (1/1)	67% (6/9)
Subsurface		73% (16/22)	40% (2/5)
Subsurface: RGCs within 50 μm		100% (8/8)	100% (1/1)
S334ter Line 4
Early stages of photoreceptor loss
Subsurface: P60–P100		75% (6/8)
Substantial photoreceptor loss
Subsurface: P180–P254		60% (24/40)
Subsurface: P180–P220		52.9% (18/34)
Subsurface: P240–P254		100% (6/6)