TABLE 6.
Plasma appearance (from biosynthesis) and disappearance rates [RJ (in μg/h)] for n−3 fatty acids in newborn infants1
Subject identification number |
||||||||||||
81 | 82 | 83 | 84 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | Mean ± SE | |
R0,1 | 25,115 | 12,144 | 25,305 | 53,173 | 46,494 | 36,744 | 9066 | 15,393 | 8612 | 31,067 | 13,017 | 25,103 ± 4649 |
R0,2 | 42 | 21 | 269 | 210 | 1 | 10 | 11 | 38 | 2 | 13 | 11 | 57 ± 28 |
R3,2 | 9.1 | 2.2 | 10.6 | 8.0 | 4.7 | 22.4 | 1.7 | 9.3 | 1.3 | 11.9 | 0.8 | 7.5 ± 1.9 |
R0,3 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 ± 0 |
R4,3 | 78 | 71 | 18 | 33 | 20 | 39 | 12 | 29 | 24 | 39 | 27 | 36 ± 6.4 |
R0,4 | 11 | 7.2 | 2 | 6 | 1 | 6 | 36 | 3 | 4 | 8 | 2 | 7.8 ± 3.0 |
R5,4 | 191 | 79 | 14 | 69 | 60 | 71 | 15 | 34 | 39 | 84 | 25 | 62 ± 15.1 |
R0,5 | 1638 | 1336 | 213 | 513 | 945 | 318 | 202 | 279 | 511 | 1074 | 579 | 692 ± 148 |
values represent the rates of disappearance (not involved in synthesis) and appearance (synthesized from its precursor) of the n−3 fatty acids. Values were determined from the fractional rate constant coefficients and plasma masses for each fatty acid. For example, R3,2 is the hourly amount of plasma 18:3n−3 involved in synthesis of 20:5n−3, and R0,1 is the turnover of 18:3n−3 in each subject.