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Schematic illustration of the possible signaling cascade through which miR-34a regulates EPC angiogenesis. Overexpression of miR-34a in EPCs induces cellular senescence and impedes in vitro angiogenesis via suppressing Sirt1. Expression of acetylated FoxO1 was augmented with miR-34a upregulation, which may mediate the effect of miR-34a on EPC angiogenesis.
