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PPARγ regulates MSC allocation. Determination of lineage allocation of MSCs is regulated by several transcription factors including PPARγ and CCAAT/enhancer binding proteins (C/EBPs), which govern adipogenesis, Runx2 (runt-related transcription factor), and Osx (osterix), which are necessary for osteoblastogenesis. PPARγ favors adipogenesis and suppresses osteoblastogenesis partly through inhibiting Runx2 function, resulting in the reduction of osteoblast pool in bone marrow.
