Table 4.
Associations of of polymorphisms in genes involved in folate uptake and distribution and risk of colorectal cancer among population-based families by folic acid supplementation and dietary folate intake
| Multivitamin use¥ | Dietary Folate∫ | |||||
|---|---|---|---|---|---|---|
| SNP* | No | Yes | Low (103.4–306.0 mcg) | High (306.1–1068 mcg) | ||
| Adjusted‡ OR (95% CI) | Adjusted‡ OR (95% CI) | p-value¶ | Adjusted‡ OR (95% CI) | Adjusted‡ OR (95% CI) | p-value¶ | |
| FOLR1 | ||||||
| rs11235464 | 1.13 (0.59–2.15) | 1.59 (0.89–2.82) | 0.28 | 1.52 (0.45–5.12) | 1.39 (0.37–5.17) | 0.78 |
| rs12361490 | 0.85 (0.70–1.04) | 1.09 (0.90–1.33) | 0.07 | 1.27 (0.88–1.84) | 0.88 (0.62–1.26) | 0.19 |
| rs2071010 | 0.84 (0.62–1.14) | 1.26 (0.96–1.66) | 0.05 | 1.03 (0.63–1.68) | 1.22 (0.71–2.11) | 0.77 |
| rs3016432 | 0.89 (0.78–1.02) | 1.14 (1.00–1.30) | <0.01 | 1.05 (0.82–1.35) | 0.96 (0.76–1.21) | 0.65 |
| rs3887687 | 0.88 (0.70–1.10) | 1.04 (0.84–1.29) | 0.39 | 1.15 (0.76–1.74) | 0.74 (0.50–1.09) | 0.15 |
| FPGS | ||||||
| rs1330684 | 0.88 (0.77–1.01) | 1.05 (0.92–1.20) | 0.01 | 1.21 (0.94–1.57) | 1.13 (0.88–1.46) | 0.33 |
| rs1544105 | 0.90 (0.79–1.02) | 1.06 (0.93–1.21) | 0.02 | 1.20 (0.94–1.53) | 1.15 (0.91–1.46) | 0.34 |
| rs4451422 | 0.90 (0.78–1.02) | 1.06 (0.93–1.21) | 0.02 | 1.19 (0.93–1.53) | 1.14 (0.90–1.46) | 0.37 |
| rs7033913 | 0.87 (0.76–1.00) | 1.02 (0.89–1.16) | 0.04 | 0.82 (0.63–1.06) | 0.80 (0.62–1.04) | 0.19 |
| GGH | ||||||
| rs10106324 | 0.88 (0.74–1.04) | 1.14 (0.97–1.33) | 0.12 | 1.21 (0.91–1.60) | 1.32 (0.98–1.77) | 0.18 |
| rs11545078 | 0.74 (0.57–0.96) | 0.99 (0.77–1.29) | 0.97 | 1.17 (0.75–1.83) | 0.92 (0.58–1.44) | 0.59 |
| rs11995525 | 0.86 (0.73–1.01) | 0.98 (0.84–1.14) | 0.79 | 0.79 (0.59–1.06) | 0.84 (0.64–1.11) | 0.25 |
| rs12548933 | 0.96 (0.79–1.17) | 1.17 (0.96–1.41) | 0.11 | 1.33 (0.97–1.81) | 0.99 (0.70–1.40) | 0.14 |
| rs13270305 | 0.72 (0.59–0.86) | 0.99 (0.83–1.18) | 0.89 | 0.91 (0.63–1.32) | 0.82 (0.58–1.16) | 0.54 |
| rs16930092 | 0.87 (0.68–1.10) | 1.08 (0.84–1.39) | 0.56 | 0.76 (0.49–1.17) | 0.86 (0.56–1.33) | 0.44 |
| rs17194931 | 0.75 (0.57–0.98) | 0.98 (0.75–1.27) | 0.88 | 1.14 (0.73–1.78) | 0.91 (0.58–1.43) | 0.64 |
| rs2736683 | 0.89 (0.76–1.05) | 0.99 (0.85–1.16) | 0.93 | 0.81 (0.60–1.09) | 0.87 (0.66–1.15) | 0.34 |
| rs3758149 | 0.80 (0.68–0.94) | 1.05 (0.89–1.23) | 0.58 | 0.91 (0.68–1.22) | 0.82 (0.61–1.09) | 0.40 |
| rs3780126 | 0.96 (0.84–1.11) | 1.05 (0.92–1.21) | 0.45 | 0.91 (0.70–1.18) | 0.90 (0.70–1.14) | 0.67 |
| rs4279586 | 0.83 (0.71–0.97) | 1.09 (0.94–1.27) | 0.25 | 1.10 (0.85–1.44) | 1.15 (0.87–1.51) | 0.61 |
| rs4617146 | 1.04 (0.87–1.24) | 1.16 (0.97–1.38) | 0.10 | 1.04 (0.77–1.42) | 0.98 (0.72–1.32) | 0.92 |
| SLC19A1 | ||||||
| rs1051266¥ | 0.89 (0.68–1.16) | 1.11 (0.86–1.43) | 0.54 | 1.11 (0.71–1.73) | 0.88 (0.57–1.36) | 0.70 |
| rs12482346 | 0.86 (0.74–0.99) | 1.02 (0.89–1.18) | 0.88 | 1.00 (0.79–1.27) | 0.96 (0.75–1.23) | 0.92 |
| rs17004785 | 1.17 (0.92–1.50) | 1.30 (1.02–1.65) | 0.03 | 1.52 (1.02–2.27) | 1.89 (1.25–2.86) | 0.01 |
| rs2236484 | 0.84 (0.73–0.97) | 1.04 (0.91–1.20) | 0.69 | 1.03 (0.81–1.31) | 1.00 (0.78–1.28) | 0.96 |
| rs2297291 | 0.87 (0.76–1.01) | 1.05 (0.91–1.21) | 0.65 | 1.00 (0.79–1.27) | 0.98 (0.77–1.25) | 0.97 |
| rs2838951 | 0.90 (0.78–1.04) | 1.05 (0.92–1.20) | 0.41 | 0.90 (0.71–1.14) | 0.83 (0.65–1.05) | 0.30 |
| rs3972 | 0.87 (0.69–1.11) | 1.01 (0.82–1.24) | 0.92 | 0.86 (0.58–1.28) | 1.27 (0.88–1.83) | 0.17 |
| rs7499 | 0.88 (0.76–1.02) | 1.04 (0.91–1.20) | 0.69 | 0.95 (0.75–1.21) | 0.99 (0.77–1.25) | 0.91 |
¥
No multivitamin use: 820 cases; 1497 controls; Yes multivitamin use: 971 cases; 1346 controls;
∫
Low dietary folate: 309 cases; 408 controls; high dietary folate: 276 cases, 429 controls;
‡
Adjusted for age and sex and matched for center and race;
*
log-additive model;
¥
recessive model;
¶
p-value for interaction