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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Gene Ther. 2009 Oct 1;17(3):315–327. doi: 10.1038/gt.2009.126

Figure 4. ΔPK-induced melanoma cell death is both calpain and caspase-dependent.

Figure 4

(a) A2058 cells were infected with ΔPK (moi = 0.5) or mock-infected with PBS and cultured without or with PD150606 (100μM), z-VAD-fmk (20μM) or both PD150606 and z-VAD-fmk. DMSO (28mM) was used as vehicle control. Replicate cultures (n = 3) were stained with EtHD at various times p.i. and the % staining cells calculated as in Fig. 2. (b) A375 cells were infected with ΔPK (moi = 0.5) in the absence or presence of inhibitors and stained with EtHD+ as in (a). ΔPK-infected WI-38 cells and mock infected, DMSO treated cells served as controls.