Table 2.

Risk for depression due to fear- and anxiety-related disorders (G2 and G3)

	HR (95% CI)a
Generation 2 (G2)
G2 MDD
Fear-related disordersb	2.9 (1.9–4.4)****
Anxiety-related disordersc	2.6 (1.2–5.6)**
G2 Childhood onset (<13 years of age) MDD
Fear-related disordersb	2.7 (1.1–6.9)**
Anxiety-related disordersc	1.8 (0.33–9.8)
G2 Adolescent onset (13–18 years of age) MDD
Fear-related disordersb	3.0 (1.7–5.5)****
Anxiety-related disordersc	3.4 (1.0–11.8)**
G2 Adult onset (19+ years of age) MDD
Fear-related disordersb	2.0 (0.97–4.3)*
Anxiety-related disordersc	2.4 (1.1–5.2)**
Generation 3 (G3)
G3 Any mood disorder
Fear-related disordersb	3.3 (1.5–7.7)***
Anxiety-related disordersc	3.7 (0.49–28.5)
G3 Childhood onset (<13 years of age) mood disorder
Fear-related disordersb	2.5 (0.83–7.4)
Anxiety-related disordersc	5.9 (0.69–52.0)
G3 Adolescent onset (13–18 years of age) mood disorder
Fear-related disordersb	4.7 (1.3–16.2)**
Anxiety-related disordersc	0.0 (0.0–0.0)

MDD, Major depressive disorder; HR, hazard ratio; CI, confidence interval.

^aAdjusted for age and correlation within family.

^bPanic/social or simple phobia.

^cOveranxious/generalized anxiety disorder.

^*p<0.1,

^**p<0.05,

^***p<0.01,

^****p<0.001.