Table 4.
Alternate and indirect effects of parental MDD on liability to depression in generations 2 and 3
| Type of effect | Parental MDD |
||
|---|---|---|---|
| Effect | BC bootstrap (95% CI)a | % | |
| Generation 2 | |||
| All MDD – fear-related disorders | |||
| Alternate | 0.67 | (0.24–1.1) | 74 |
| Indirect | 0.23 | (0.05–0.55)* | 26 |
| Mediator – fear-related disorders | 0.30 | (0.02–0.50)* | |
| All MDD – anxiety-related disorders | |||
| Alternate | 0.86 | (0.41–1.3)* | 91 |
| Indirect | 0.09 | (−0.07 to 0.32) | 9 |
| Mediator – anxiety-related disorders | 0.20 | (−0.19 to 0.55) | |
| G2 Fear-related disorders by developmental phase | |||
| Childhood MDD | |||
| Alternate | 0.64 | (0.003–1.3) | 80 |
| Indirect | 0.16 | (−0.11 to 0.48) | 20 |
| Mediator – fear-related disorders | 0.19 | (−0.17 to 0.46) | |
| Adolescent MDD | |||
| Alternate | 0.07 | (−0.45 to 0.68) | 13 |
| Indirect | 0.46 | (0.17–0.91)* | 87 |
| Mediator – fear-related disorders | 0.49 | (0.19–0.69)* | |
| Adult MDD | |||
| Alternate | 0.66 | (0.18–1.2)* | 86 |
| Indirect | 0.11 | (−0.09 to 0.43) | 14 |
| Mediator – fear-related disorders | 0.17 | (−0.15 to 0.49) | |
| Generation 3 | |||
| All mood disorders | |||
| Alternate | 0.29 | (−0.47 to 0.99) | 42 |
| Indirect | 0.40 | (0.005–0.90)* | 58 |
| Mediator – fear-related disorders | 0.44 | (−0.07 to 0.71) | |
| Adolescent onset mood disorder | |||
| Alternate | 0.45 | (−0.64 to 1.6) | 40 |
| Indirect | 0.72 | (0.13–1.6)* | 60 |
| Mediator – fear-related disorders | 0.62 | (0.02–0.88)* | |
MDD, Major depressive disorder; BC, bias corrected; CI, confidence interval.
*
Intervals not including zero significant at p<0.05.