Fig. 8.
Relaxation of porcine pulmonary artery to DETA NO after 48-h incubation with this nitrovasodilator (10−4 M) in the presence and absence of MG-132 (3 × 10−6 M). After incubation, the vessels were repeatedly rinsed and preconstricted with U46619 (3 × 10−7 M) to similar tension levels before the effect of DETA NO was tested. Data are means ± SE; n = 4–6 for each group. *P < 0.05, significant difference between vessels treated with DETA NO and those treated with solvent or MG-132. †P < 0.05, significant difference between vessels treated with DETA NO and those treated with MG-132 plus DETA NO.