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. 2010 Apr 16;299(1):L36–L50. doi: 10.1152/ajplung.00427.2009

Table 2.

Genes with expression increased >5-fold during cell culture

Abundance (f. u.)
Gene Title Day5/Day 0 GO Biological Process/Molecular Function
Collagen, type I, α1 14.2 skeletal development
Aquaporin 4 11.4 Transport
Solute carrier organic anion transporter family, 2A1 11.1 Lipid transport
Ankyrin repeat domain 1 (cardiac muscle) 10.9 Defense response
Spectrin, β, nonerythrocytic 1 10.2 Barbed-end actin filament capping
Milk fat globule-EGF factor 8 protein 9.9 Cell adhesion
Prenylcysteine oxidase 1 9.5 Prenylated protein catabolism
Chloride intracellular channel 3 8.6 Ion transport/signal transduction
Protein Sα 8.6 Blood coagulation
Growth arrest-specific 6 8.2 Regulation of cell growth/signal transduction
UDP glucuronosyltransferase 1 family, A6 8.1 Xenobiotic metabolism
Down syndrome critical region gene 1-like 1 8.1 Central nervous system development
Chloride intracellular channel 5 7.5 Ion transport
Transgelin 7.3 Muscle development
Solute carrier family 16 (monocarboxylic acid), 4 7.2 Transport
Collagen, type IV, α3 (Goodpasture antigen) 7.2 Phosphate transport/apoptosis/ signal transduction
Aminoadipate-semialdehyde synthase 6.8 Electron transport
ATP-binding cassette, sub-family C (CFTR/MRP), 3 6.4 Transport
Adhesion molecule with Ig-like domain 2 6.2 Cell adhesion
Solute carrier family 15 (H+/peptide transporter), 2 6.1 Oligopeptide transport
Claudin 18 6.0 Calcium-independent cell-cell adhesion
Cystatin E/M 5.7 Morphogenesis
Fatty acid desaturase 2 5.7 Fatty acid biosynthesis
Collagen, type IV, α2 5.5 Phosphate transport
Midkine (neurite growth-promoting factor 2) 5.5 Regulation of cell cycle/signal transduction
Kallmann syndrome 1 sequence 5.5 Cell motility/chemotaxis
Thrombospondin 1 5.5 Cell motility/cell adhesion
Stearoyl-CoA desaturase (delta-9-desaturase) 5.2 Fatty acid biosynthesis
Collagen, type IV, alpha 1 5.1 Phosphate transport
Metallothionein 1M 5.1 Metal ion binding

Data are means for 5 experiments; P < 0.003 day 5 vs. day 0.