Table 4.
Genes repressed >3-fold by dexamethasone plus cAMP
| Gene Title | DCI/Control | GO Biological Process/Molecular Function |
|---|---|---|
| BMP & activin membrane-bound inhibitor | 0.17 | |
| Likely ortholog of mouse limb-bud and heart gene | 0.17 | |
| Serpin peptidase inhibitor, clade B (ovalbumin), 2 | 0.19 | Anti-apoptosis |
| Adhesion molecule with Ig-like domain 2 | 0.20 | Cell adhesion |
| Solute carrier organic anion transporter family, 2A1 | 0.20 | Lipid transport |
| Thrombospondin 1 | 0.21 | Cell motility/cell adhesion |
| Dickkopf homolog 1 (Xenopus laevis) | 0.22 | Development/Wnt receptor signaling pathway |
| Potassium channel tetramerisation domain containing 12 | 0.22 | Potassium ion transport |
| NADPH oxidase 4 | 0.23 | Electron transport |
| MARCKS-like 1 | 0.23 | |
| Caldesmon 1 | 0.29 | Muscle contraction/development |
| Protease, serine, 23 | 0.25 | Proteolysis |
| Ectodermal-neural cortex (with BTB-like domain) | 0.26 | Development |
| Sema domain, immunoglobulin domain (semaphorin) 3C | 0.26 | Immune response/tyrosine kinase signaling |
| Plasminogen activator, urokinase | 0.27 | Proteolysis |
| Collagen, type I, α1 | 0.27 | Skeletal development |
| Growth arrest and DNA-damage-inducible, α | 0.27 | Regulation of cyclin dependent protein kinase |
| Collagen, type IV, α3 (Goodpasture antigen) | 0.27 | Phosphate transport/apoptosis/signal transduction |
| Interleukin-32 | 0.28 | Immune response/cell adhesion |
| Immediate early response 3 | 0.28 | Apoptosis |
| Protease, serine, 2 (trypsin 2) | 0.28 | Proteolysis |
| Cystatin E/M | 0.28 | Morphogenesis |
| Laminin, γ2 | 0.28 | Cell adhesion |
| K intermed/small conductance Ca-activated channel N 4 | 0.29 | Ion transport |
| Neuregulin 1 | 0.29 | Nervous system development/transcription |
| Integrin, α2 (CD49B, α2 subunit of VLA-2 receptor) | 0.29 | Cell adhesion |
| Transforming growth factor, β2 | 0.29 | Regulation of cell cycle |
| Integrin, β6 | 0.30 | Cell adhesion/integrin-mediated signaling pathway |
| Glutathione S-transferase M3 (brain) | 0.30 | Establishment of blood-nerve barrier |
| Collagen, type IV, α4 | 0.30 | Phosphate transport |
| Collagen, type IV, α2 | 0.31 | Phosphate transport |
| Complement component 5 | 0.31 | Inflammatory response/chemotaxis |
| Tumor necrosis factor receptor superfamily, member 21 | 0.31 | Apoptosis/signal transduction |
| Tropomyosin 1α | 0.31 | Regulation of muscle contraction |
| Chromosome 2 open reading frame 23 | 0.32 | |
| Cadherin 2, type 1, N-cadherin (neuronal) | 0.32 | Cell adhesion |
| Polo-like kinase 2 (Drosophila) | 0.33 | Protein amino acid phosphorylation |
| ATPase, Class V, type 10A | 0.33 | Cation transport |
| Plasminogen activator, urokinase receptor | 0.33 | Signal transduction/regulation of proteolysis |
| S100 calcium binding protein A2 | 0.33 |
Data are means of 5 experiments; P < 0.003 for DCI-treated vs. control.