Table 7.
Twenty-five genes of adult cells with decreased expression in control culture and hormone induction in both fetal and adult cells: candidate genes for hormonal responsiveness in vivo
| Adult Cells |
Fetal Cells |
|||
|---|---|---|---|---|
| Gene Title | Signal | Fold Induction | Fold Induction | GO Biological Process/Molecular Function |
| Progastricsin (pepsinogen C) | 4,316 | 59.1 | 49.7 | Proteolysis |
| Dual oxidase 1 | 959 | 21.8 | 3.4 | Electron transport/H2O2 biosynthesis |
| Cartilage acidic protein 1 | 393 | 9.7 | 3.6 | Cell adhesion |
| WNT inhibitory factor 1 | 1,659 | 7.4 | 12.9 | Signal transduction/development |
| Chemokine (C-C motif) ligand 20 | 699 | 6.4 | 8 | Chemotaxis |
| Secretory leukocyte peptidase inhibitor | 5,074 | 5.6 | 8.8 | Endopeptidase inhibitor activity |
| Surfactant protein C | 2,473 | 5.4 | 123.8 | Respiratory gaseous exchange |
| Carbonic anhydrase XII | 140 | 5.3 | 3.7 | One-carbon compound metabolism |
| TSC22 domain family, member 3 | 489 | 4.3 | 2.2 | Regulation of transcription |
| CCAAT/enhancer binding protein δ | 1,264 | 4.3 | 5 | Transcription |
| N-myc downstream regulated gene 1 differentiation | 1,882 | 4.2 | 2.3 | Response to metal ion/cell |
| Solute carrier family 6 (aa transporter) 14 | 1,928 | 3.9 | 12.2 | Amino acid metabolism |
| S100 calcium binding protein P | 789 | 3.6 | 3.5 | Endothelial cell migration |
| A kinase (PRKA) anchor protein 13 | 507 | 3.5 | 2.1 | Intracellular signaling cascade |
| Interferon stimulated exonuclease 20 kDa | 223 | 3.4 | 5.7 | DNA catabolism |
| Carbonic anhydrase II | 135 | 3.2 | 2.4 | One-carbon compound metabolism |
| Protocadherin 9 | 170 | 3.2 | 4.1 | Cell adhesion |
| Surfactant protein B | 5,601 | 2.9 | 17.1 | Respiratory gaseous exchange |
| Regulator of G protein signalling 2, 24 kDa | 142 | 2.9 | 4.8 | Cell cycle/TK signal transduction |
| Endothelin receptor type B transduction | 70 | 2.5 | 2.7 | Regulation adenylate cyclase/signal |
| B-cell CLL/lymphoma 6 (ZFP 51) | 627 | 2.3 | 1.9 | Negative regulation of transcription |
| Nuclear receptor subfamily 4, group A 2 | 40 | 2.3 | 6.1 | Transcription |
| Adipose differentiation-related protein | 484 | 2.3 | 2 | Lipid metabolism |
| Anterior gradient 2 homolog | 1,953 | 1.9 | 11.6 | |
| Surfactant protein A2 | 6,765 | 1.9 | 145.6 | Respiratory gaseous |
| Exchange/immune defense | ||||
Data are mean values from 5 experiments for mRNA abundance (signal as fluorimetric units) and fold induction by DCI during culture. Data for fetal cells are adapted from Wade et al. (61).