Figure 1.

The effects of pre-exposure to the training and testing context (PTC) or to a different context (PDC) on strategy selection of male mice. (A) Schematic diagram of the water plus-maze. Mice were released from the south arm during training trials and from the north arm during the probe test. (B) More male mice used place strategy than response strategy when pre-exposed to the same context prior to training and testing (PTC, n = 5) compared with male mice pre-exposed to a different context (PDC, n = 7, P < 0.05). (C) Latency curves show the actual latency to escape to the platform. Two-way ANOVA (non-repeated measures) revealed no significant difference across training trials in escape latencies between PDC and PTC mice (P > 0.5), although a significant effect of trial indicated that mice reduced their escape latencies across trials (P < 0.001). Values represent mean ± S.E.M.