Table 1.
Dependence of secretagog responses on sAC: inhibition by KH7
1st Peak | 2nd Peak | Sustained | |
---|---|---|---|
Epi | +19.2 ± 27.1 | −107.7 ± 6.2 | |
Epi + KH7 | +82.6 ± 34.4* | −39.7 ± 9.0* | |
PGE2 | +220.3 ± 7.0 | +169.3 ± 13.1 | +17.7 ± 28.7 |
PGE2 + KH7 | +363.9 ± 13.2* | +307.0 ± 27.2* | +115.2 ± 15.9* |
Short-circuit current (Isc) values (μA/cm2) are means ± SE, n = 4, stimulated as in Fig 2. sAC, soluble adenylyl cyclase; epi, epinephrine.
Responses with KH7 (30 μM) significantly different from control (P < 0.05).