Table 3.

Dependence of secretagog responses on HCO₃⁻/CO₂ buffer: sensitivity to bicarb-free conditions

	1st Peak	2nd Peak	Sustained
Epi: control	+123.7 ± 21.1		−137.3 ± 8.3*
Epi: bicarb free	+166.6 ± 29.2†		−83.9 ± 3.0*†
PGE2: control	+265.3 ± 17.4	+204.0 ± 20.0	+19.1 ± 13.2
PGE2: bicarb free	+385.1 ± 29.4†	+259.9 ± 23.0†	+56.1 ± 6.8†
CCh: control	+747.0 ± 27.7	+927.1 ± 29.6	+338.6 ± 28.7
CCh: bicarb free	+842.7 ± 36.5†	+884.0 ± 68.1	+222.1 ± 22.0†

I_sc values (μA/cm²) are means ± SE, n = 7, stimulated as in Fig 7.

^*BIIE0246 was present for all responses, except sustained epi in which peptide YY replaced BIIE0246.

^†Responses in bicarbonate (bicarb)-free conditions significantly different from control (P < 0.05).