Fig. 9.
Surface pH, damage progression, and epithelial repair measured during HCO3− transport inhibition with H2DIDS. A: extracellular gastric surface pH (pHo) was measured before (open bar) and after (hatched bar) photodamage, using C57BL/6 mice in pH 3 perfusate without (control, n = 6) or with 0.5 mM H2DIDS (n = 5) in the pH 3 perfusate. SLC26A9 KO (n = 4) were also examined in the presence of H2DIDS. B: initial size was measured immediately after photodamage, and maximal damage was evaluated over the first 10 min after photodamage. C: epithelial repair was evaluated as the time taken for the damage size to return to or below initial size. Means ± SE, *P < 0.05 and ***P < 0.001 vs. C57BL6 (- PD); *P < 0.05 and **P < 0.01 vs. initial size.