Table 2.

Effects of drugs on gastrointestinal transit

Parameter	Placebo	Tolterodine	Darifenacin (7.5 mg)	Darifenacin (15 mg)
Gastric emptying, thalf, min	125.5 ± 6.7	127 ± 6.4	115.4 ± 6.4	120.4 ± 6.7
Colonic filling at 6 h, %	59.6 ± 6.4	47.1 ± 6	34.4 ± 6.1†	20.4 ± 6.3†‡
Colonic transit
Ascending colonic emptying, thalf, h	12.0 ± 1.5	14.0 ± 1.0	18.6 ± 1.9*	22.9 ± 2.6†‡
GC24	2.8 ± 0.2	2.7 ± 0.2	2.4 ± 0.2	1.9 ± 0.2†‡
GC48	3.8 ± 0.2	4 ± 0.2	3.6 ± 0.2	3.4 ± 0.2

All values represent least squares means (95% CI), adjusted for gender and BMI. GC₂₄ and GC₄₈, geometric center of oclonic transit at 24 and 48 h, respectively.

^*P = 0.02;

^†P < 0.01 vs. placebo;

^‡P < 0.01 vs. tolterodine.