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. 2010 Apr 23;299(1):H114–H124. doi: 10.1152/ajpheart.00028.2010

Fig. 4.

Fig. 4.

MT1-MMP activity and functional significance. A: activity of MT1-MMP was measured in aortic homogenates from normal and TAA-induced mice using an MT1-MMP-specific quenched fluorogenic peptide activity assay. The results demonstrated elevated MT1-MMP activity (in ng·mg GAPDH−1·h−1) at 2, 4, and 16 wk post-TAA induction (*P < 0.05 vs. reference control animals; #P < 0.05 vs. 2 wk). B: pairwise regression analysis was performed between MT1-MMP activity (in ng·mg GAPDH−1·h−1) and the time-dependent change in aortic diameter (in mm). The results demonstrated a significant correlation (r = 0.4142, P = 0.0205), suggesting that MT1-MMP activity is required for aortic dilatation during TAA development. Linear mixed model analysis demonstrated that significant predictors of MT1-MMP activity included aortic diameter (F = 16.85, P = 0.0004), time (F = 6.09, P = 0.0205), and the interaction between aortic diameter and time (F = 7.62, P = 0.0104).