Fig. 6.

Effects of IRTX on peak MAP and HR responses during static contraction (A) and during intra-arterial injection of capsaicin (B). The data from the 15 rats injected with IRTX were combined. Values under the x-axis labels are their baseline values. A: the peak MAP and HR values during static contraction were significantly increased from their respective baselines (*P < 0.05). IRTX (10 μg) had no significant effect on the peak pressor response to static contraction (P = 0.272), whereas the antagonist significantly decreased the peak cardioaccelerator responses to contraction (P = 0.007). B: the peak MAP and HR responses to capsaicin injection in femoral circulation were significantly attenuated by pretreatment of IRTX. Horizontal brackets signify that the increases are significantly different from each other (†P < 0.05). Values are means ± SE (n = 15).