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. 2010 May 14;299(1):H217–H224. doi: 10.1152/ajpheart.00065.2010

Fig. 4.

Fig. 4.

Before the initiation of A-V pacing, interstitial matrix metalloproteinase (MMP) activity was similar between the remote region and the region at which ventricular pacing would be applied. With A-V pacing, interstitial MMP activity was higher in the V-paced region by 120 min, and this effect was not observed in the remote region (top). Interstitial MMP activity within the V-paced region was normalized for simultaneous changes in the interstitial MMP activity in the remote region (bottom) to account for systematic alterations in MMP activity during the protocol. A significant increase in interstitial MMP activity was observed during A-V pacing, which persisted with the restoration of atrial-only pacing. *P < 0.05 vs. the remote region.