Table 1.
Physiological parameters and plasma measurements in control and HCT-treated rats
| Parameter | LZRs | OZRs | HCT-Treated LZRs | HCT-Treated OZRs | Strain Effect? | Drug Effect? |
|---|---|---|---|---|---|---|
| Body mass, g | 401 ± 10 | 595 ± 15* | 340 ± 6† | 560 ± 11* | Yes | Yes |
| Heart mass, g | 1.18 ± 0.05 | 1.33 ± 0.04* | 0.97 ± 0.02† | 1.17 ± 0.03*† | Yes | Yes |
| Kidney mass, g | 1.34 ± 0.05 | 1.75 ± 0.18* | 1.07 ± 0.03† | 1.45 ± 0.04*† | Yes | Yes |
| Insulin, μg/l | 1.2 ± 0.5 | 5.4 ± 0.9* | 0.3 ± 0.1 | 5.4 ± 0.8* | Yes | No |
| Triglycerides, mg/dl | 72.6 ± 10.4 | 277.3 ± 56.0* | 32.0 ± 11.0 | 316.5 ± 49.9* | Yes | No |
| Cholesterol, mg/dl | 70.6 ± 6.7 | 121.5 ± 16.7* | 55.1 ± 5.2 | 115.7 ± 8.3* | Yes | No |
Values are means ± SE. LZRs, lean Zucker rats; OZRs, obese Zucker rats; HCT, hydrochlorthiazide.
*
P < 0.05 vs. treatment-matched LZRs;
†
P < 0.05 vs. strain-matched untreated rats.