Table 2.

Effect of l-NAME on systemic and pulmonary arterial pressure and on cardiac output

		Systemic Arterial Pressure, mmHg		Pulmonary Arterial Pressure, mmHg		Normalized Cardiac Output, ml·min−1·100 gms−1
	n	Control	l-NAME	Control	l-NAME	Control	l-NAME	Increase in Pulmonary Vascular Resistance, mmHg·ml−1·min−1
1 mg/kg iv	6	109 ± 7	133 ± 8*	19 ± 1	25 ± 1*	36 ± 3	33 ± 4	0.11 ± 0.05*
5 mg/kg iv	15	97 ± 4	123 ± 4*	18 ± 3	24 ± 1*	32 ± 1	23 ± 1	0.15 ± 0.03*
10 mg/kg iv	11	101 ± 4	134 ± 6*	17 ± 1	28 ± 1*	32 ± 2	24 ± 2	0.23 ± 0.02*
50 mg/kg iv	20	88 ± 4	128 ± 6*	16 ± 1	27 ± 1*	33 ± 1	21 ± 1	0.25 ± 0.02*
100 mg/kg iv	24	96 ± 2	141 ± 3*	18 ± 1	28 ± 1*	27 ± 1	16 ± 1	0.32 ± 0.02*

Values are means ± SE.

^*P < 0.05 compared with control. l-NAME, nitro-l-arginine methyl ester.