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Airway responsiveness [enhanced pause (Penh)] to methacholine (MCh) in A1KO and A1WT mice. Values are expressed as means ± SE; n = 4–8 mice. On y-axis, Penh is expressed as percentage of the vehicle. *P < 0.05, A1WT SEN and SEN (S) + AD compared with A1WT CON; #P < 0.05, A1KO SEN and SEN + AD compared with A1KO CON.
