Table 5.

Effects on sympathetic BAT thermogenic and cardiovascular parameters of Ponto-Med TranX and of subsequent nanoinjection of Bic into VLM

	Intact Control	Ponto-Med TranX	Bic in VLM
n	6	6	6
BAT SNA, %control	100	776 ± 197*	162 ± 39‡
BAT Temp, °C	34.1 ± 0.5	36.2 ± 0.4†	35.0 ± 0.3§
ΔBAT Temp, °C		+2.0 ± 0.3	−1.2 ± 0.2
Exp CO2, %	3.8 ± 0.4	4.3 ± 0.4*	3.8 ± 0.4‡
ΔExp CO2, %		+0.5 ± 0.1	−0.5 ± 0.1
HR, beats/min	424 ± 26	495 ± 14†	360 ± 47‡
ΔHR, beats/min		+71 ± 18	−135 ± 43
MAP, mmHg	94 ± 4	111 ± 5*	145 ± 15§
ΔMAP, mmHg		+16 ± 5	+34 ± 7

Values are means ± SE; n, no. of rats. Ponto-Med TranX, pontomedullary transection. The values for BAT SNA are expressed as percentage of intact, pretransection control levels. Mean parameter values for “Ponto-Med TranX” are the group means of the parameter values during the 1-min interval representing the peak response within 15 min of completing the transection, and the corresponding changes for “Ponto-Med TranX” are relative to the mean control parameter values during a 1-min interval just before transection. Mean parameter values for “Bic in VLM” are the group means of the parameter values during the 1-min interval representing the peak response within 5 min of the nanoinjection of Bic into VLM, and the corresponding changes for “Bic in VLM” are relative to the “Ponto-Med TranX” parameter values. Core (rectal) temperatures were maintained between 36.5 and 37.5°C with a servo-controlled heating lamp. Statistically significant compared with intact control value:

^*P< 0.05,

^†P< 0.01; and from “Ponto-Med TranX” value:

^‡P< 0.05;

^§P< 0.01.