Table 2.
Pulmonary function and gas exchange
| COPD |
Healthy Control |
|||
|---|---|---|---|---|
| Absolute | Percent predicted | Absolute | Percent predicted | |
| FVC, liters | 2.9 ± 0.2 | 70.6 ± 6.1 | 4.6 ± 0.4* | 99.6 ± 6.9 |
| FEV1 | 1.6 ± 0.1 | 48.3 ± 4.2 | 3.6 ± 03* | 99.2 ± 7.8 |
| FEV1/FVC, % | 55.0 ± 4.7 | 68.6 ± 5.8 | 79.2 ± 2.7* | 99.0 ± 3.4 |
| SVC, liters | 3.5 ± 0.2 | 84.4 ± 5.1 | 4.9 ± 0.4* | 107.0 ± 6.4 |
| IC, liters | 2.9 ± 0.2 | 102.1 ± 7.4 | 3.8 ± 0.3* | 125.0 ± 10.0 |
| ERV, liters | 0.6 ± 0.1 | 44.4 ± 6.4 | 1.1 ± 0.4* | 69.4 ± 13.2 |
| RV, liters | 2.9 ± 0.4 | 121.6 ± 14.4 | 2.9 ± 0.1 | 113.7 ± 4.9 |
| VTG, liters | 4.0 ± 0.3 | 127.6 ± 8.7 | 3.8 ± 0.3* | 100.0 ± 5.1 |
| TLC, liters | 6.9 ± 0.3 | 109.7 ± 4.6 | 7.6 ± 0.5 | 110.9 ± 5.2 |
| FEF25%, l/s | 2.1 ± 0.4 | 28.3 ± 5.9 | 7.9 ± 0.8* | 99.6 ± 11.6 |
| FEF50%, l/s | 0.9 ± 0.2 | 22.8 ± 4.5 | 3.9 ± 0.6* | 87.6 ± 16.9 |
| FEF75%, l/s | 0.4 ± 0.1 | 24.0 ± 3.4 | 1.7 ± 0.3* | 106.6 ± 23.7 |
| MVV, l/min | 70.9 ± 9.4 | 48.9 ± 6.4 | 160.7 ± 10.4* | 108.6 ± 8.0 |
| DlCO, ml•min−1•mmHg−1 | 15.1 ± 1.4 | 64.5 ± 7.3 | 29.7 ± 1.5* | 117.6 ± 7.7 |
| Dl/Va | 2.4 ± 0.3 | 53.6 ± 7.1 | 4.0 ± 0.2* | 78.0 ± 6.2 |
Values represent means ± SE. FVC, forced vital capacity; FEV1, forced expiratory volume in 1 s; FEV1/FVC, ratio of forced expiratory volume in 1 s to forced vital capacity; SVC, slow vital capacity; IC, inspiratory capacity; ERV, expiratory reserve volume; RV, residual volume; VTG, thoracic gas volume; TLC, total lung capacity; FEF25%, FEF50%, and FEF75%, forced expiratory flow at 25%, 50%, and 75% of FVC, respectively; MVV, maximal voluntary ventilation; DlCO, diffusing capacity of the lung for carbon monoxide; Dl/Va, ratio of lung diffusion capacity to lung volume.
*
P < 0.05 vs. COPD.