Table 1.
Systemic and stenotic kidney function in pigs with unilateral RAS and ARAS
| Normal | RAS | ARAS | |
|---|---|---|---|
| No. of kidneys | 8 | 26 | 22 |
| Body wt, kg | 48.3 ± 1.0 | 46.6 ± 1.3 | 48.6 ± 5.3 |
| Degree of stenosis, % | 0 | 64.7 ± 4.5* | 63.8 ± 4.2* |
| Total cholesterol, mmol/l | 2.2 ± 0.1 | 2.1 ± 0.1 | 10.2 ± 0.2*† |
| PRA, pg/ml | 0.3 ± 0.5 | 2.85 ± 1.4 | 2.4 ± 1.5 |
| Mean arterial pressure, mmHg | 98.8 ± 2.3 | 117 ± 4.3* | 117.6 ± 4.5* |
| GFR, ml/min | 80.7 ± 5.4 | 51.0 ± 3.5* | 56.4 ± 4.0* |
| Renal blood flow, ml/min | 584 ± 13 | 347.7 ± 30* | 324.1 ± 30* |
| Renal volume, ml/kg | 2.31 ± 0.07 | 1.86 ± 0.07* | 1.60 ± 0.08*† |
| Perfusion, ml·min−1·ml−1 | |||
| Cortex | 4.7 ± 0.2 | 3.8 ± 0.2* | 3.8 ± 0.2* |
| Medulla | 3.1 ± 0.3 | 2.2 ± 0.3 | 2.0 ± 0.3* |
| RVR, mmHg·ml−1·min−1 | |||
| Basal | 0.17 ± 0.01 | 0.39 ± 0.05* | 0.34 ± 0.03* |
| ACh | 0.14 ± 0.02 ‡ | 0.30 ± 0.03*‡ | 0.33 ± 0.02* |
| ITC basal | |||
| Proximal | 3.94 ± 0.3 | 4.74 ± 0.3 | 4.30 ± 0.4 |
| Henle's | 5.04 ± 0.4 | 5.38 ± 0.7 | 5.22 ± 0.4 |
| Distal | 6.82 ± 0.7 | 6.92 ± 0.3 | 5.85 ± 0.3*† |
| ITC ACh | |||
| Proximal | 3.05 ± 0.2‡ | 3.32 ± 0.1‡ | 3.53 ± 0.3‡ |
| Henle's | 3.99 ± 0.7‡ | 3.75 ± 0.4‡ | 4.80 ± 0.6 |
| Distal | 4.72 ± 0.6‡ | 4.86 ± 0.1‡ | 5.10 ± 0.6 |
Values are means ± SE. RAS, renal artery stenosis; ARAS, atherosclerotic renal artery stenosis; PRA, plasma renin activity; GFR, glomerular filtration rate, RVR, renal vascular resistance; ITC, intratubular fluid concentration (arbitrary units). P < 0.05 vs. normal (*), vs. RAS (†), and vs. baseline (‡).