Fig. 10.

Reevaluation of sodium and water intake and output in the Aldo-infused mPGES-1 WT and KO mice with a second protocol. Following implantation of the minipump driving Aldo infusion at 0.35 mg·kg⁻¹·day⁻¹, the animals were placed on a low-salt diet for 3 days and then switched to a normal-salt diet to allow escape to occur. At the indicated time points of the switch in diet, animals were placed in metabolic cages, and sodium and water intake and output were determined. Day 0 corresponds to the last day of low-salt treatment. A–F are defined as in the legend for Fig. 9. Values are means ± SE; n = 7/group. *P < 0.05 WT at the corresponding period.