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. Author manuscript; available in PMC: 2010 Jul 14.
Published in final edited form as: J Cell Sci. 2008 Nov 11;121(Pt 23):3981–3990. doi: 10.1242/jcs.033431

Figure 1. RUNX1/AML1 and AML1-ETO are targeted to distinct subnuclear locations.

Figure 1

Immunofluorescence microscopy for endogenous RUNX1/AML1 (red) and AML1-ETO (green) with DAPI staining (blue) in Kasumi-1 cells as well as merged images are shown. RUNX1/AML1 and AML1-ETO fusion protein are predominantly present in the nucleus but do not co-localize in the Kasumi-1 cells. An antibody detecting ETO was used to visualize the AML1-ETO fusion protein, whereas an antibody recognizing the C-terminal domain of RUNX1/AML1 was used to detect endogenous RUNX1/AML1.