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Optimization of the cyclization conditions
 | ||||
|---|---|---|---|---|
| Reagent |
Solvent |
t |
T °C |
Result |
| Me4NOAc | MeCN | 3 h | 130 | no desired product |
| Me4NOAc | MeCN | 12 h | 130 | polymerization |
| NaOH | H2O/DMSO | 12 h | 130 | polymerization |
| LiI | DMF | 12 h | 120 | no desired product |
| TBAI, LiI | DMF/H2O | 12 h | 130 | Polymerization |
| HCl(1M) | H2O | 24 h | 130 | 24% 6, 18% 7 |
| HCl (conc) | H2O | 6 h | 130 | 99% 7 |
