Table 2.

Effect of neurotransmitter antagonists on the inhibitory modulation of neuronal activity

Condition	Control	Antagonist	Recovery
Inhibitory neurotransmitter antagonists
Bicuculline (5 μm)	−31  ± 5% (15)	−13  ± 3% (17)*	−26  ± 3% (16)*
Strychnine (1 μm)	−28  ± 5% (20)	−8  ± 3% (17)*	−25  ± 4% (19)*
Bicuculline + strychnine	−28  ± 4% (28)	0  ± 1% (23)*	−20  ± 2% (32)*
Glutamate antagonists
NBQX (10 μm)	−25  ± 5% (22)	−6  ± 3% (22)*	−15  ± 2% (23)*
D-AP7 (200 μm)	−24  ± 5% (21)	−12  ± 4% (18)**	−22  ± 5% (14)
NBQX + D-AP7	−18  ± 2% (19)	−2  ± 2% (19)*	−12  ± 3% (18)*

Shown are the average modulation values for trials when a Ca²⁺ wave reached the neuron. Only neurons with significant inhibitory modulation were tested. Antagonists were applied for 15 min before testing. Recovery followed a 60 min washout.

* p < 0.01, antagonist versus control, recovery versus antagonist.

** p < 0.05.