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. 1998 Jun 1;18(11):4022–4028. doi: 10.1523/JNEUROSCI.18-11-04022.1998

Table 2.

Effect of neurotransmitter antagonists on the inhibitory modulation of neuronal activity

Condition Control Antagonist Recovery
Inhibitory neurotransmitter antagonists
 Bicuculline (5 μm) −31  ± 5% (15) −13  ± 3% (17)* −26  ± 3% (16)*
 Strychnine (1 μm) −28  ± 5% (20) −8  ± 3% (17)* −25  ± 4% (19)*
 Bicuculline + strychnine −28  ± 4% (28) 0  ± 1% (23)* −20  ± 2% (32)*
Glutamate antagonists
 NBQX (10 μm) −25  ± 5% (22) −6  ± 3% (22)* −15  ± 2% (23)*
 D-AP7 (200 μm) −24  ± 5% (21) −12  ± 4% (18)** −22  ± 5% (14)
 NBQX + D-AP7 −18  ± 2% (19) −2  ± 2% (19)* −12  ± 3% (18)*

Shown are the average modulation values for trials when a Ca2+ wave reached the neuron. Only neurons with significant inhibitory modulation were tested. Antagonists were applied for 15 min before testing. Recovery followed a 60 min washout.

p < 0.01, antagonist versus control, recovery versus antagonist.

** p < 0.05.