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. 2010 Apr 14;299(1):C164–C174. doi: 10.1152/ajpcell.00512.2009

Fig. 12.

Fig. 12.

Effect of MDL72527 on renal function after endotoxin-induced AKI. The effect of PAO inhibition on the renal function of animals was determined 24 h post-LPS administration by measuring their serum creatinine levels. Animals given intraperitoneal injection of LPS or saline were treated with 100 mg/kg MDL72527 or vehicle (n = 8/group). Serum creatinine levels of saline-injected animals treated with MDL72527 or vehicle were not significantly different (P ≥ 0.05). Animals given intraperitoneal LPS injection and then treated with MDL72527 had significantly (*P ≤ 0.05) lower serum creatinine levels than LPS-treated animals receiving vehicle. Serum creatinine levels of the LPS-treated mice were significantly (+P ≤ 0.01) higher than those of saline-treated animals.