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. 2010 Mar 31;299(1):C148–C154. doi: 10.1152/ajpcell.00405.2009

Fig. 4.

Fig. 4.

A: urea released in the extracellular medium by control RBC or RBC pretreated for 60 min with increasing concentrations of FP and then incubated for 16 h at 37°C in the presence of 5 mM l-Arg. Results are expressed as absolute values (mM) or per milligram of Hb. Results are means ± SD of 4 experiments. *P < 0.01 vs. control. B: urea released in the extracellular medium (n = 5 experiments) by control RBC, RBC pretreated for 60 min with 40 μM FP or HP, or RBC pretreated for 3 hrs with Fe=ascorbate (Fe-Asc, 0.3–0.5 mM). CO-FP indicates that the RBC suspension was exposed for 10 min to a carbon monoxide atmosphere before treatment with 40 μM FP. Bars represent means and 95% confidence intervals (CI). Comparison over all groups: P < 0.001 (4 df); paired comparisons with control: *P = 0.04 by Wilcoxon signed-rank test.