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Cholesterol depletion abrogates the effect of Cer on HERG kinetics. HERG-expressing cells were pretreated for 30 min with either 5 mM methyl-β-cyclodextrin (MβCD; n = 5) or 5 mM MβCD conjugated with cholesterol (Chol; n = 6) prior to Cer application. Cer-induced changes in V1/2 (A), fast deactivation τ (B), and slow deactivation τ (C) are depicted. *P < 0.05; **P < 0.01.
