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Reduced tear film hypertonicity in AQP5 knockout mice by prevention of evaporation. (A) Tear film [Na+] measured before and after 20-minute exposure of mice to a 100% humidified atmosphere (SE, four eyes from two mice; filled circles). Averaged (± SE) values are shown as open circles. *P < 0.005). (B) Schematic of the determinants of tear film osmolality show the replacement of evaporative water loss by AQP5-facilitated osmotic water transport across the ocular surface epithelium.
