Table 1.
Pilot study cohort characteristics
| HFHS-3 | HFHS-4 | UMSCC-10A | UMSCC-1 | UMSCC-98 | |
|---|---|---|---|---|---|
| HPV status | HPV16 | HPV16 | HPV16 | Not detected | HPV16 |
| p53 mutation | NI1 | NI1 | Yes2 | Yes3 | NI1 |
| Smoking & alcohol | yes | yes | NI1 | NI1 | NI1 |
| Stage | 4 | 2 | 3 | 2 | 4 |
| Site | Larynx | Tongue | Larynx | Floor of mouth | Larynx |
| Age (years) | 58 | 58 | 57 | 73 | 75 |
| Gender | Male | Male | Male | Male | Male |
NI=no information
Yes=- (Gly-> Cys) in codon 245
Yes= AGA->AGT (Arg->Ser) in codon 280 and a 30 base pair deletion in exon 8, codons 277–287