Table 2.

Endoscopic and histologic findings in 9 patients

Patient	Colon mucosal findings1	Colon Histology2				T cells % FOXP3+
		Surface	Crypts	Lamina Propria	Other
#1	Normal	PMN				4.80
#2	Erythema, Edema			Increased PMN, eosinophils		5.63
#3	Erythema, Edema, Friability, Erosions		Apoptotic bodies	Increased lymphocytes, plasma cells, eosinophils		3.06
#4	Erythema, Edema, Friability	Lymphocytes	Microabscesses, PMN, eosinophils	Increased plasma cells		8.81
#5	Erythema, Friability		Microabscesses, PMN, lymphocytes, eosinophils	Increased PMN, eosinophils, lymphocytes, plasma cells,		1.51
#6	Erythema, Ulcers	PMN	PMN	Increased PMN, lymphocytes, plasma cells		4.02
#7	Erythema, Edemea, Exudate, Friability, Ulcers, Bleeding		PMN	Increased PMN, eosinophils, lymphocytes, plasma cells,		3.90
#8	Erythema, Edema, Exudate, Ulcers	Lymphocytes	Apoptotic bodies, architectural distortion, microabscesses	Increased lymphocytes, plasma cells, eosinophils		1.21
#9	Erythema, Edema, Friability, Exudate, Ulcers, Denuded mucosa	Thin epithelium	Apoptotic bodies, architectural distortion, microabscesses	Increased PMN, lymphocytes, plasma cells	Crypt loss	3.56

¹Based on the findings at all endoscopic examinations following ipilimumab.

²Based on the histologic findings from all colon mucosal biopsies. PMN= neutrophils.