Table 2.
Baseline characteristics
| Overall |
5–7 years |
8–11 years |
12–15 years |
≥ 16 years |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | Observed Mean ± SD |
n | Observed Mean ± SD |
n | Observed Mean ± SD |
n | Observed Mean ± SD |
n | Observed Mean ± SD |
|
| Weight (kg) | 54 | 22.1 ± 7.1 | 7 | 16.3 ± 1.9 | 25 | 20.4 ± 6.8 | 8 | 23.5 ± 4.8 | 14 | 27.2 ± 7.0 |
| Height (cm) | 54 | 101.9 ± 12.1 | 7 | 96.1 ± 6.9 | 25 | 100.4 ± 12.0 | 8 | 99.3 ± 11.1 | 14 | 108.9 ± 12.7 |
| Z-score1 | −6.6 | −4.4 | −5.7 | −8.3 | −8.3 | |||||
| BMI (kg/m2) | 54 | 21.0 ± 3.7 | 7 | 17.6 ± 1.5 | 25 | 20.0 ± 3.1 | 8 | 23.9 ± 3.5 | 14 | 22.8 ± 4.0 |
| Z-score1 | 1.1 | 1.2 | 1.3 | 1.4 | 0.4 | |||||
| Urine GAG (µg/mg creatinine) |
54 | 338 ± 111 | 7 | 373 ± 121 | 25 | 329 ± 119 | 8 | 364 ± 59 | 14 | 319 ± 117 |
| Albumin (g/dL)*2 | 50 | 4.3 ± 0.4 | 7 | 4.3 ± 0.4 | 24 | 4.3 ± 0.4 | 8 | 4.2 ± 0.6 | 11 | 4.5 ± 0.4 |
| Range | (3.2, 5.3) | (3.7, 4.8) | (3.2, 5.3) | (3.4, 5.1) | (3.5, 5.0) | |||||
| Tanner score | ||||||||||
| 1 | 34 | 7 | 23 | 1 | 3 | |||||
| 2 | 11 | 0 | 2 | 6 | 3 | |||||
| 3 | 2 | 0 | 0 | 1 | 1 | |||||
| 4 | 4 | 0 | 0 | 0 | 4 | |||||
| 5 | 3 | 0 | 0 | 0 | 3 | |||||
Summary statistics calculated using measures at study entry, rather than treatment baseline;
1
Z-scores based on World Health Organization 2007 tables;
2
Normal Range: Albumin (3.9–5.4 for 5 yr to adult); (Harriet-Lane 2002).