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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Semin Hematol. 2010 Jul;47(3):243–248. doi: 10.1053/j.seminhematol.2010.02.005

Figure 1.

Figure 1

Mechanism of activation of TPO receptor by TPO, romiplostim, and eltrombopag. The TPO receptor has been proposed to exist as an inactive preformed dimer (left) with proximal (CRH-1) and distal (CRH-2) cytokine receptor homology (CRH) domains. Upon binding of thrombopoietin of ?or? romiplostim to the distal CRH-2 domain or binding of eltrombopag to the transmembrane region, the receptor (right) conformation changes and a number of signal transduction pathways are activated that increase platelet production.