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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Semin Hematol. 2010 Jul;47(3):243–248. doi: 10.1053/j.seminhematol.2010.02.005

Figure 2.

Figure 2

Structure of romiplostim. Romiplostim is composed of the Fc (fragment “crystallized”) portion of IgG1 to which two 14-amino acid TPO peptides (purple) are coupled via glycine bridges (green) at the carboxy-terminus of each γ heavy chain. Interchain (at cysteines C7 and C10) and intrachain (cysteines C42-C102, C148-C206) disulfide bridges are indicated in red. Heavy chain constant domains 2 (CH2) and 3 (CH3) are also shown. Romiplostim has a molecular weight of ∼60 kDa.