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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Neurobiol Aging. 2010 Aug;31(8):1401–1418. doi: 10.1016/j.neurobiolaging.2010.04.029

Figure 1. Group Differences in Pattern of Reduction in Grey Matter (GM) Density over 12 Months in the ADNI Cohort.

Figure 1

Time x diagnosis group interactions demonstrate differences in atrophy progression reflected by reduction in GM density from baseline to 1-year in the ADNI cohort (n=643*; 143 AD, 57 MCI-C, 253 MCI-S, 190 HC). Interaction contrasts are displayed at a threshold of p<0.0001 (unc.) with a minimum cluster size (k) = 27 voxels. Cross-sections in (a–e) are (0, −9, 0, coronal) and (0, −23, −16, axial), left to right. Cross-section in (f) is (34, −29, 64, coronal). (*30 participants removed from comparisons due to failed image processing)