Table 1.
Demographic Information and Neuropsychological Test Scores (Mean (SE))
AD (n=152) |
MCI-C (n=60) |
MCI-S (n=261) |
HC (n=200) |
p-value | Significant Pair Comparisons (p<0.05) |
|
---|---|---|---|---|---|---|
Baseline Age | 75.33 (0.5) | 74.04 (0.9) | 75.07 (0.4) | 75.95 (0.5) | NS | none |
12mo Age | 76.41 (0.5) | 75.11 (0.9) | 76.15 (0.4) | 77.04 (0.5) | NS | none |
Education | 14.82 (0.2) | 15.15 (0.4) | 15.89 (0.2) | 16.08 (0.2) | p<0.001 | HC, MCI-S>AD |
Gender (M, F) | 80, 72 | 35, 25 | 166, 95 | 105, 95 | p=0.06 | MCI-S vs. AD, HC |
Handedness (R, L) | 144, 8 | 55, 5 | 239, 22 | 185, 15 | NS | none |
ApoE Genotype (% ApoE4+) | 65.13% | 58.33% | 54.79% | 28.00% | p<0.001 | AD, MCI-C, MCI-S>HC |
Baseline CDR-SoB | 4.18 (0.1) | 2.00 (0.1) | 1.52 (0.1) | 0.02 (0.1) | p<0.001 | AD>MCI-C>MCI-S>HC |
12mo Change in CDR-SoBa | +2.13 (0.1) | +2.64 (0.2) | +1.26 (0.1) | +1.1 (0.1) | p<0.001 | AD, MCI-C>MCI-S, HC |
Baseline MMSE | 23.53 (0.1) | 26.58 (0.2) | 27.11 (0.1) | 29.11 (0.1) | p<0.001 | HC>MCI-S, MCI-C >AD |
12mo Change in MMSEb | −1.88 (0.7) | −2.56 (0.4) | −0.35 (0.2) | 0.00 (0.2) | p<0.001 | HC, MCI-S>MCI-C, AD |
Baseline RAVLTc | 23.25 (0.7) | 26.20 (1.1) | 32.00 (0.5) | 43.65 (0.6) | p<0.001 | HC>MCI-S>MCI-C, AD |
12mo Change in RAVLTd | −2.91 (0.5) | −2.68 (0.8) | −0.81 (0.4) | +0.3 (0.5) | p<0.001 | HC>MCI-C, AD; MCI-S>AD |
Baseline ICV | 1552677.32 (13807.5) |
1566297.83 (21976.7) |
1570616.06 (10537.0) |
1534944.90 (12037.1) |
NS | none |
7 participants missing data (2 AD, 1 MCI-S, 4 HC)
2 participants missing data (1 MCI-S, 1 HC)
3 participants missing data (1 AD, 2 HC)
14 participants missing data (8 AD, 3 MCI-S, 3 HC)