. 2010 May 27;9:145. doi: 10.1186/1475-2875-9-145

Table 5.

Effect of IV challenge dose on perceived vaccine efficacy

	pcDNA^a)	pCSP(-A) ^a)

Challenge	Infected/total	Infected/total	Efficacy

10,000 SPZ/IV	10/10	8/10	20%
3000 SPZ/IV	9/9	7/10	22%
1000 SPZ/IV	8/10	7/10	12.5%
300 SPZ/IV	9/10	5/10	44%
100 SPZ/IV	7/10	0/10	100%

5000 SPZ/SQ	9/10	0/10	100%

a) Three DNA immunizations of BALB/c mice delivered by gene gun (3 shots/immunization, 1 μg plasmid/shot), empty control plasmid (pcDNA) or CSP-encoding plasmid (plasmid and immunization described previously [30,34]. All animals were challenged with sporozoites from the same batch of infected mosquitoes. Results were confirmed in independent repeat experiments