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. 2010 Jul 14;5(7):e11411. doi: 10.1371/journal.pone.0011411

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Nilsson et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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We detected a variety of PC ion species in the global MALDI IMS scans of lung tissue. Shown here is the distribution profile of PC m/z 674.6 detected as a raw image by pixel location (A) and as contours of the ion intensity (color code: aqua/high intensity, blue/medium intensity) that have been re-plotted onto scanned images of the original sample after histological processing and staining (B). PC m/z 674.6 was closely associated with the location of small bronchioles throughout the lung section. Deconvolution of the H&E stained image (C) allowed clearer visualization of these bronchioles (indicated by arrows) supporting this observation. The MALDI matrix CHCA was applied by an automatic sprayer device.